Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973993 | 0.91 | GABRG2 (0.55) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340367 | 0.89 | GABRG2 (0.72) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342596 | 0.86 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7991356 | 0.85 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7987417 | 0.83 | GABRA1 (0.53) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341232 | 0.82 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340744 | 0.81 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7963518 | 0.81 | GABRG2 (0.60) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7972319 | 0.80 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL342931 | 0.79 | GABRG2 (0.77) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | claimed |
| EP-1056747-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | claimed |
| WO-1999037649-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | claimed |
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | disclosed |
| EP-1056747-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037649-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |