Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 18/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 17/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340897 | 0.89 | GABRG2 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL340682 | 0.86 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7984476 | 0.83 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341135 | 0.81 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL339263 | 0.80 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6988047 | 0.80 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341428 | 0.79 | GABRG2 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2646458 | 0.78 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL341244 | 0.78 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL342117 | 0.77 | GABRG2 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | claimed |
| US-6319924-B1 | FOR THERAPY OF DELETERIOUS MENTAL STATES | MERCK SHARP & DOHME LTD. (GB) | 2001-11-20 | — | — | US | disclosed |
| EP-1056747-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037649-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |