Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534986 | 0.79 | TSHR (0.44) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL6534996 | 0.78 | TSHR (0.46) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL6534959 | 0.73 | TSHR (0.48) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL6534892 | 0.71 | TSHR (0.46) | TSHRGABRA1GABRB2POLBLMNA | |
| SCHEMBL6535026 | 0.71 | TSHR (0.42) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL22444557 | 0.70 | TSHR (0.48) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL7984562 | 0.70 | TSHR (0.44) | TSHRGABRA1GABRB2POLBHTR1A | |
| SCHEMBL6534841 | 0.70 | TSHR (0.44) | TSHRGABRA1GABRB2POLBLMNA | |
| SCHEMBL7996169 | 0.70 | TSHR (0.41) | TSHRGABRA1GABRB2PTGS2 | |
| SCHEMBL4236181 | 0.69 | TSHR (0.43) | TSHRGABRA1GABRB2POLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |