Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584106 | 0.73 | ALDH1A1 (0.39) | PDE10AALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7983133 | 0.73 | PDE4B (0.45) | PDE10AALDH1A1CYP17A1POLBKMT2A | |
| SCHEMBL6586794 | 0.72 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDCYP3A4CYP2C9 | |
| SCHEMBL6586097 | 0.69 | ENPP1 (0.63) | PDE10ACYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6588310 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDCYP3A4CYP2C9 | |
| SCHEMBL24861080 | 0.68 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDCYP3A4CYP2C9 | |
| SCHEMBL6589108 | 0.68 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDCYP3A4CYP2C9 | |
| SCHEMBL6248830 | 0.68 | ALDH1A1 (0.38) | PDE10AALDH1A1HPGDCYP3A4HSD17B10 | |
| SCHEMBL7984800 | 0.68 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584375 | 0.66 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |