Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.61 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HLA-A | P04439 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876975 | 0.85 | NR4A2 (0.44) | KCNH2NR4A2SOS1LMNACYP1A2 | |
| SCHEMBL7984722 | 0.84 | KCNH2 (0.60) | KCNH2NR4A2SOS1SSTR5LMNA | |
| SCHEMBL4982569 | 0.83 | SSTR5 (0.52) | KCNH2NR4A2SSTR5LMNACYP1A2 | |
| SCHEMBL5110805 | 0.82 | KCNH2 (0.65) | KCNH2NR4A2SOS1SSTR5LMNA | |
| SCHEMBL7500613 | 0.82 | KCNH2 (0.65) | KCNH2NR4A2SSTR5LMNAALDH1A1 | |
| SCHEMBL9687041 | 0.81 | KDM4E (0.52) | SSTR5LMNAGAAALDH1A1HTT | |
| SCHEMBL9697200 | 0.80 | KCNH2 (0.62) | KCNH2NR4A2SOS1SSTR5LMNA | |
| SCHEMBL11265895 | 0.80 | KCNH2 (0.83) | KCNH2NR4A2SOS1SSTR5LMNA | |
| Bromide SCHEMBL11305424 | 0.79 | KCNH2 (0.81) | KCNH2NR4A2SOS1SSTR5LMNA | |
| SCHEMBL7988153 | 0.79 | KCNH2 (0.70) | KCNH2NR4A2SOS1SSTR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |