Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 5/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143693 | 0.80 | KDM4E (0.85) | KDM4EL3MBTL1NPC1BRD4MITF | |
| SCHEMBL1839896 | 0.80 | IDO1 (0.50) | KDM4EL3MBTL1NPC1BRD4MITF | |
| SCHEMBL28219034 | 0.78 | TYR (0.52) | KDM4EIDO1EP300HTTMAPT | |
| SCHEMBL14199087 | 0.77 | CYP1A2 (0.44) | L3MBTL1TDP1 | |
| SCHEMBL1839673 | 0.77 | KDM4E (0.42) | KDM4EL3MBTL1NPC1BRD4MITF | |
| SCHEMBL647824 | 0.77 | LTA4H (0.45) | L3MBTL1TSHRTDP1ALDH1A1MAPK1 | |
| SCHEMBL29618448 | 0.77 | LTA4H (0.45) | L3MBTL1TSHRTDP1ALDH1A1MAPK1 | |
| SCHEMBL10110677 | 0.76 | TYR (0.54) | KDM4EIDO1EP300HTTMAPT | |
| SCHEMBL17799251 | 0.76 | KDM4E (0.82) | KDM4EL3MBTL1NPC1BRD4MITF | |
| SCHEMBL14008508 | 0.75 | KDM4E (0.60) | KDM4EL3MBTL1NPC1BRD4MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |