Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 12/20 | 0.47 |
| ▸ | HEXB | P07686 | 12/20 | 0.47 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131231 | 0.99 | HEXA (0.48) | HEXAHEXBOGASIRT1TERT | |
| SCHEMBL8138008 | 0.82 | HEXA (0.58) | HEXAHEXBOGASIRT1TERT | |
| SCHEMBL8126116 | 0.81 | HEXA (0.54) | HEXAHEXBOGASIRT1TERT | |
| Bromide SCHEMBL7972531 | 0.80 | TERT (0.45) | HEXAHEXBTERT | |
| SCHEMBL7985052 | 0.79 | HEXA (0.50) | HEXAHEXBOGATERT | |
| SCHEMBL7982362 | 0.79 | HEXA (0.51) | HEXAHEXBOGASIRT1TERT | |
| SCHEMBL8126468 | 0.79 | TERT (0.46) | HEXAHEXBTERT | |
| SCHEMBL8129190 | 0.78 | SIRT1 (0.63) | HEXAHEXBOGASIRT1TERT | |
| SCHEMBL8129861 | 0.77 | HEXA (0.55) | HEXAHEXBOGASIRT1DYRK3 | |
| SCHEMBL8122059 | 0.77 | HEXA (0.55) | HEXAHEXBOGASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300340-B1 | USEFUL FOR THERAPY OF CANCER AND SOLID TUMORS | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| US-6162822-A | Bisimide compounds | ADIR ET COMPAGNIE (FR) | 2000-12-19 | — | — | US | disclosed |