Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.67 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.67 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806828 | 0.87 | TRPC3 (0.64) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL789016 | 0.81 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL10080529 | 0.80 | TRPC3 (0.58) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL1704212 | 0.78 | KMT2A (0.57) | TRPC3TRPC6L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL807013 | 0.76 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL4927035 | 0.75 | CCR4 (0.57) | TRPC3TRPC6L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL10080528 | 0.71 | RAB9A (0.58) | TRPC3TRPC6SMN1; SMN2HPGDRAB9A | |
| SCHEMBL10080531 | 0.71 | TRPC3 (0.58) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL10080530 | 0.71 | TRPC3 (0.63) | TRPC3TRPC6L3MBTL1MDM2SMN1; SMN2 | |
| SCHEMBL10464759 | 0.70 | RAB9A (0.62) | L3MBTL1SMN1; SMN2HPGDRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | claimed |
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |