Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 4/20 | 0.64 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080529 | 0.88 | TRPC3 (0.58) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL798510 | 0.87 | TRPC3 (0.67) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL790485 | 0.81 | NPC1 (0.55) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL10080530 | 0.79 | TRPC3 (0.63) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL789016 | 0.78 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL798484 | 0.76 | NPC1 (0.55) | TRPC3TRPC6L3MBTL1NPC1RAB9A | |
| SCHEMBL807013 | 0.76 | TRPC3 (1.00) | TRPC3TRPC6L3MBTL1MDM2NPC1 | |
| SCHEMBL10080532 | 0.71 | TRPC3 (0.54) | TRPC3TRPC6NPC1RAB9AHPGD | |
| SCHEMBL10080527 | 0.70 | TRPC3 (0.66) | TRPC3TRPC6NPC1RAB9AHPGD | |
| SCHEMBL789085 | 0.70 | NPC1 (0.98) | TRPC3TRPC6L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |