Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 7/20 | 1.00 |
| ▸ | TRPC6 | Q9Y210 | 7/20 | 1.00 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771772 | 0.83 | TRPC3 (1.00) | TRPC3TRPC6MDM2L3MBTL1ALDH1A1 | |
| SCHEMBL807014 | 0.81 | TRPC3 (0.73) | TRPC3TRPC6MDM2L3MBTL1ALDH1A1 | |
| SCHEMBL789016 | 0.80 | TRPC3 (1.00) | TRPC3TRPC6MDM2L3MBTL1ALDH1A1 | |
| SCHEMBL23771822 | 0.78 | TRPC3 (1.00) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL28712408 | 0.77 | TRPC3 (0.68) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL28717655 | 0.77 | TRPC3 (0.65) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL798510 | 0.76 | TRPC3 (0.67) | TRPC3TRPC6MDM2L3MBTL1ALDH1A1 | |
| SCHEMBL806828 | 0.76 | TRPC3 (0.64) | TRPC3TRPC6MDM2L3MBTL1ALDH1A1 | |
| SCHEMBL23771825 | 0.75 | TRPC3 (1.00) | TRPC3TRPC6NPC1PTGS2RAB9A | |
| SCHEMBL21536306 | 0.74 | HTT (0.72) | ALDH1A1SMN1; SMN2HPGDNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037349-A2 | COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |