Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 4/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903929 | 0.95 | PRKCA (0.44) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL16500321 | 0.89 | PRKCA (0.46) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL2881252 | 0.89 | ALDH1A1 (0.47) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL2814667 | 0.89 | ALDH1A1 (0.47) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL29169775 | 0.89 | PRKCA (0.59) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL4903933 | 0.86 | PRKCA (0.46) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL4914069 | 0.85 | ALDH1A1 (0.47) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL27878028 | 0.82 | PRKCA (0.65) | PRKCAPRKCEPRKCQPRKCDMEN1 | |
| Galactitol SCHEMBL23924274 | 0.82 | PRKCA (0.58) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL6810153 | 0.80 | MAPT (0.41) | PRKCAPRKCEPRKCQPRKCDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225325-B1 | ADMINISTERING N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL OR GALACTITOL FOR PROPHYLAXIS, THERAPY, REDUCING, OR REVERSING MULTIDRUG RESISTANCE IN PATIENT UNDERGOING THERAPY WITH CHEMOTHERAPEUTIC AGENT | G.D. SEARLE & COMPANY | 2001-05-01 | — | — | US | disclosed |