Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | AMPD1 | P23109 | 2/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.38 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7974102 | 0.98 | TLR8 (0.46) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL7988227 | 0.98 | TLR8 (0.45) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL7974495 | 0.94 | ADORA2A (0.48) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| Hydrochloric Acid SCHEMBL7984737 | 0.92 | ADORA2A (0.47) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL7985623 | 0.87 | ADORA2A (0.45) | ADORA2A | |
| SCHEMBL18050894 | 0.85 | TLR8 (0.41) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL18050888 | 0.83 | TLR8 (0.42) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL7988189 | 0.80 | ADORA2A (0.42) | ALDH1A1ADORA2A | |
| SCHEMBL28819811 | 0.77 | TLR8 (0.51) | TLR8ALDH1A1TDP1ADORA2AKMT2A | |
| SCHEMBL7992360 | 0.75 | ADRA1D (0.46) | ADORA2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |