Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974316 | 0.96 | TP53 (0.48) | HPGDKDM4ENPSR1P2RX7TP53 | |
| SCHEMBL7985852 | 0.93 | TP53 (0.52) | TP53RXFP1GAAROCK2ROCK1 | |
| SCHEMBL7974195 | 0.91 | GAA (0.48) | HPGDKDM4EP2RX7TP53RXFP1 | |
| SCHEMBL7974586 | 0.90 | GAA (0.52) | P2RX7TP53RXFP1GAA | |
| SCHEMBL7991676 | 0.90 | ACP1 (0.43) | P2RX7GRIN1GRIN2BROCK2ROCK1 | |
| SCHEMBL7985381 | 0.90 | HPGD (0.48) | HPGDP2RX7TP53RXFP1CYP1A2 | |
| SCHEMBL7988752 | 0.90 | TP53 (0.48) | HPGDKDM4ENPSR1TP53RXFP1 | |
| SCHEMBL7991877 | 0.89 | P2RX7 (0.47) | P2RX7TP53RXFP1CYP1A2CYP3A4 | |
| SCHEMBL7974021 | 0.88 | TP53 (0.51) | P2RX7TP53RXFP1CYP1A2CYP3A4 | |
| SCHEMBL7985655 | 0.88 | TP53 (0.48) | HPGDTP53RXFP1GAAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |