Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985865 | 1.00 | SIGMAR1 (0.50) | SIGMAR1OPRM1JAK2JAK1STS | |
| SCHEMBL20046753 | 0.85 | RARB (0.41) | GPR119 | |
| SCHEMBL17086784 | 0.85 | KMT2A (0.49) | JAK2JAK1STSNAMPTRORC | |
| SCHEMBL3151932 | 0.85 | KMT2A (0.49) | JAK2JAK1STSNAMPTRORC | |
| SCHEMBL3151938 | 0.85 | KMT2A (0.49) | JAK2JAK1STSNAMPTRORC | |
| SCHEMBL20046028 | 0.82 | HRH3 (0.46) | NAMPTGPR119 | |
| SCHEMBL20046352 | 0.82 | HRH3 (0.46) | NAMPTGPR119 | |
| SCHEMBL20046024 | 0.81 | GPR119 (0.46) | NAMPTGPR119 | |
| SCHEMBL8527336 | 0.81 | SIGMAR1 (0.51) | SIGMAR1OPRM1 | |
| SCHEMBL20046750 | 0.80 | KCNJ1 (0.40) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |