SCHEMBL7985946

SCHEMBL7985946

C=COC(=O)N1C2CCC1CC(C#N)(c1cncc(Br)c1)C2

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RIPK2 O43353 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
GRM5 P41594 1/20 0.31
L3MBTL4 Q8NA19 1/20 0.31
L3MBTL3 Q96JM7 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7228279 0.88 GRM5 (0.33) RIPK2NPSR1GRM5
SCHEMBL7223958 0.88 NPSR1 (0.34) RIPK2NPSR1GRM5
SCHEMBL7696111 0.88 GRM5 (0.37) RIPK2NPSR1GRM5
SCHEMBL7223294 0.88 GRM5 (0.33) RIPK2NPSR1GRM5
SCHEMBL6618477 0.88 RIPK2 (0.32) RIPK2
SCHEMBL7223856 0.84 CYP11B2 (0.35) RIPK2NPSR1GRM5
SCHEMBL16554354 0.83 NPSR1 (0.35) RIPK2NPSR1L3MBTL4L3MBTL3L3MBTL1
SCHEMBL16115082 0.83 CHRM2 (0.39) RIPK2GRM5
SCHEMBL17507206 0.83 CHRM2 (0.39) RIPK2GRM5
SCHEMBL16116308 0.83 CHRM2 (0.39) RIPK2GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294545-B1 INSECTICIDES SYNGENTA LIMITED (GB) 2001-09-25 US disclosed
EP-1033914-A1 BICYCLIC AMINES AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 2000-09-13 EP disclosed
WO-1999026478-A1 BICYCLIC AMINES AND THEIR USE AS INSECTICIDES ZENECA LIMITED (GB) 1999-06-03 WO disclosed