Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986145 | 1.00 | SIGMAR1 (0.50) | SIGMAR1OPRM1CYP2D6ACHE | |
| SCHEMBL18701025 | 0.80 | ACHE (0.49) | SIGMAR1ACHE | |
| SCHEMBL3165429 | 0.79 | MC4R (0.48) | SIGMAR1ACHE | |
| SCHEMBL3165425 | 0.79 | MC4R (0.48) | SIGMAR1ACHE | |
| SCHEMBL7986503 | 0.78 | KDM4E (0.56) | ACHE | |
| SCHEMBL7986506 | 0.78 | KDM4E (0.56) | ACHE | |
| SCHEMBL7983055 | 0.78 | SIGMAR1 (0.66) | SIGMAR1OPRM1 | |
| SCHEMBL7983052 | 0.78 | SIGMAR1 (0.66) | SIGMAR1OPRM1 | |
| SCHEMBL14067225 | 0.78 | MAPT (0.47) | SIGMAR1ACHE | |
| SCHEMBL9641794 | 0.76 | SIGMAR1 (0.41) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |