Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 3/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984711 | 0.91 | ABCC8 (0.44) | ABCC8KCNJ11NR1H4ICMTCACNA1H | |
| SCHEMBL7987680 | 0.87 | HPGD (0.42) | GSK3BHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7987555 | 0.86 | GAA (0.47) | GSK3BHDAC1HDAC2 | |
| SCHEMBL8061779 | 0.85 | GSK3B (0.40) | GSK3BFLT1KDR | |
| SCHEMBL7984694 | 0.83 | NR1H4 (0.53) | NR1H4EPHX2HDAC1HDAC3HDAC4 | |
| SCHEMBL7985500 | 0.82 | NR1H4 (0.48) | ABCC8KCNJ11NR1H4FLT1KDR | |
| SCHEMBL7991372 | 0.81 | NR1H4 (0.49) | NR1H4CACNA1HEPHX2HDAC1HDAC3 | |
| SCHEMBL7988379 | 0.81 | KDM4E (0.50) | GSK3BHDAC1CACNA1G | |
| SCHEMBL7988995 | 0.80 | NR1H4 (0.38) | ABCC8KCNJ11NR1H4ICMTCACNA1H | |
| SCHEMBL7991550 | 0.80 | GAA (0.45) | EPHX2HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |