Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987555 | 0.88 | GAA (0.47) | HPGDGSK3BMAPTCYP1A2MEN1 | |
| SCHEMBL8061779 | 0.87 | GSK3B (0.40) | HPGDGSK3B | |
| SCHEMBL7984382 | 0.87 | NPC1 (0.41) | GSK3BTP53MAPTKDM4EALDH1A1 | |
| SCHEMBL7986341 | 0.87 | GSK3B (0.43) | GSK3BHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7988379 | 0.83 | KDM4E (0.50) | GSK3BTP53MAPTADORA1KDM4E | |
| SCHEMBL7991550 | 0.82 | GAA (0.45) | HPGDADORA1ALDH1A1HDAC1HDAC2 | |
| SCHEMBL7988471 | 0.81 | KDM4E (0.43) | GSK3BCYP1A2KDM4ELMNA | |
| SCHEMBL7987935 | 0.81 | XDH (0.47) | HPGDMEN1KMT2AALDH1A1HDAC1 | |
| SCHEMBL7973987 | 0.80 | FGFR1 (0.45) | MAPTKMT2ACYP11B1CYP11B2ADORA3 | |
| SCHEMBL7985361 | 0.80 | P2RY14 (0.52) | KDM4EALDH1A1CNR1CNR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |