Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991550 | 0.93 | GAA (0.45) | GAAPKMTSHRALDH1A1POLB | |
| SCHEMBL7987935 | 0.92 | XDH (0.47) | GAAPKMTSHRALDH1A1MEN1 | |
| SCHEMBL7991565 | 0.90 | TSHR (0.49) | GAAPKMTSHRALDH1A1KMT2A | |
| SCHEMBL8061779 | 0.89 | GSK3B (0.40) | GSK3BCDK8HPGDGSK3AJAK3 | |
| SCHEMBL7988379 | 0.89 | KDM4E (0.50) | GSK3BMAPTMAPK1MMP13HDAC1 | |
| SCHEMBL7987680 | 0.88 | HPGD (0.42) | GSK3BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7988471 | 0.88 | KDM4E (0.43) | GAAGSK3BPOLBCYP1A2CYP3A4 | |
| SCHEMBL7984382 | 0.87 | NPC1 (0.41) | PKMGSK3BALDH1A1MAPTAURKA | |
| SCHEMBL7986341 | 0.86 | GSK3B (0.43) | GSK3BHDAC1HDAC2 | |
| SCHEMBL7984368 | 0.86 | GSK3B (0.44) | GAATSHRGSK3BALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |