Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10812162 | 0.90 | HRH1 (0.39) | HRH1HTR2ATDP1TAAR1GABBR2 | |
| SCHEMBL5478216 | 0.89 | TSHR (0.36) | HRH1HTR2ATDP1TAAR1GABBR2 | |
| SCHEMBL30312009 | 0.89 | AOC3 (0.42) | HRH1HTR2ATAAR1SIGMAR1 | |
| SCHEMBL1310414 | 0.89 | TRPA1 (0.44) | HRH1HTR2ATDP1TAAR1GABBR2 | |
| SCHEMBL6529288 | 0.86 | TRPA1 (0.39) | HRH1HTR2ATDP1TAAR1GABBR2 | |
| SCHEMBL11566039 | 0.83 | RIPK1 (0.36) | HRH1HTR2ATDP1TAAR1GABBR2 | |
| SCHEMBL2172475 | 0.81 | HRH1 (0.56) | HRH1HTR2ATDP1TAAR1CYP1A2 | |
| SCHEMBL30171026 | 0.79 | HRH1 (0.54) | HRH1HTR2ATDP1TAAR1CYP1A2 | |
| SCHEMBL3683571 | 0.78 | CYP1A2 (0.51) | GABBR2GABBR1CYP1A2CYP2D6PKM | |
| SCHEMBL9452584 | 0.78 | HTR2A (0.43) | HRH1HTR2ATAAR1GABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |