Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986402 | 0.86 | HRH1 (0.42) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL1310414 | 0.85 | TRPA1 (0.44) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL10812162 | 0.82 | HRH1 (0.39) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL8037637 | 0.82 | TRPA1 (0.42) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL8274952 | 0.82 | TRPA1 (0.48) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL1546696 | 0.82 | TRPA1 (0.48) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL1507699 | 0.82 | TRPA1 (0.48) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL148756 | 0.81 | TRPA1 (0.48) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 | |
| SCHEMBL657128 | 0.79 | GABBR2 (0.41) | GABBR2GABBR1CYP2D6CYP1A2SMN1; SMN2 | |
| SCHEMBL28830488 | 0.78 | TRPA1 (0.41) | TRPA1GABBR2GABBR1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455483-B2 | Compounds—801 | ASTRAZENECA AB (SE) | 2013-06-04 | — | — | US | disclosed |
| US-20110053909-A1 | Compounds - 801 | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053909-A1 | Compounds - 801 | ADRA2C, ADRB2, ADRB1 | TRPA1 184/4885GABBR2 446/4885GABBR1 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.