Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 2/20 | 0.41 |
| ▸ | F11 | P03951 | 2/20 | 0.41 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986710 | 1.00 | LTB4R (0.48) | LTB4RLTB4R2LRRK2FFAR1RORC | |
| SCHEMBL4565149 | 0.83 | LTB4R (0.54) | LTB4RLTB4R2FFAR1RORCCAMK2A | |
| SCHEMBL4565147 | 0.83 | LTB4R (0.54) | LTB4RLTB4R2FFAR1RORCCAMK2A | |
| SCHEMBL29737932 | 0.79 | PTGDR2 (0.41) | CAMK2AL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL20562760 | 0.79 | PTGDR2 (0.41) | CAMK2AL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL29383625 | 0.76 | HSD17B10 (0.54) | MEN1ALDH1A1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL426773 | 0.76 | HSD17B10 (0.54) | MEN1ALDH1A1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL25931866 | 0.75 | PTGDR2 (0.38) | CAMK2APOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL29844957 | 0.74 | THRB (0.47) | CAMK2ALMNAL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL16898291 | 0.74 | THRB (0.47) | CAMK2ALMNAL3MBTL1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |