Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | FLT4 | P35916 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554934 | 0.93 | KDR (0.55) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7504511 | 0.92 | KDR (0.54) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7551047 | 0.90 | KDR (0.51) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7552915 | 0.89 | KDR (0.51) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7987137 | 0.88 | KDR (0.74) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7550357 | 0.84 | KDR (0.78) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7548486 | 0.84 | KDR (0.41) | KDRFLT1FLT4GRIN2BSMO | |
| SCHEMBL7990966 | 0.82 | KDR (0.63) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7987886 | 0.82 | KDR (0.63) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7550081 | 0.82 | KDR (0.56) | KDRFLT1FLT4PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |