Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | TTPA | P49638 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003203 | 0.92 | MAPT (0.64) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL9530470 | 0.90 | MAPT (0.50) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL9075891 | 0.89 | MAPT (0.50) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL7492850 | 0.86 | MAPT (0.59) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL9630761 | 0.85 | TDP1 (0.48) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL9632107 | 0.84 | MAPT (0.60) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL8619704 | 0.84 | MAPT (0.57) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL7487350 | 0.84 | MEN1 (0.52) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL8172995 | 0.82 | TDP1 (0.43) | MAPTMEN1KMT2ATDP1PPARG | |
| SCHEMBL7492546 | 0.80 | MAPT (0.53) | MAPTMEN1KMT2ATDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000010994-A1 | PROCESS FOR THE PREPARATION OF 2-(ARYLOXYMETHYL)-2,5,7,8-TETRAMETHYLCHROMAN-6-OLS | SANKYO COMPANY, LIMITED (JP) | 2000-03-02 | — | — | WO | claimed |
| WO-2000010994-A1 | PROCESS FOR THE PREPARATION OF 2-(ARYLOXYMETHYL)-2,5,7,8-TETRAMETHYLCHROMAN-6-OLS | SANKYO COMPANY, LIMITED (JP) | 2000-03-02 | — | — | WO | disclosed |
| WO-2000008009-A1 | PROCESS FOR THE PREPARATION OF 2-(AMINOPHENOXYMETHYL) CHROMANS | SANKYO COMPANY, LIMITED (JP) | 2000-02-17 | — | — | WO | disclosed |
| EP-0556830-B1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1996-04-24 | — | — | EP | disclosed |
| US-5310952-A | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans | LONZA LTD. (CH) | 1994-05-10 | — | — | US | disclosed |
| EP-0556830-A1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1993-08-25 | — | — | EP | disclosed |