SCHEMBL7987060

SCHEMBL7987060

CCOC(=O)Cc1cc2c(s1)CCN(C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1Cl)NC(=O)OC(C)(C)C)C2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.43
MC4R P32245 3/20 0.42
MC3R P41968 2/20 0.37
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 5/20 0.35
LMNA P02545 1/20 0.34
DRD2 P14416 1/20 0.34
PPARG P37231 1/20 0.34
PPARA Q07869 1/20 0.34
MAPT P10636 3/20 0.33
GAA P10253 2/20 0.33
KDM4E B2RXH2 1/20 0.33
PKM P14618 1/20 0.33
HPGD P15428 1/20 0.33
ALOX12 P18054 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
KMT2A Q03164 1/20 0.32
ITGB2 P05107 1/20 0.32
ICAM1 P05362 1/20 0.32
ITGAL P20701 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7985559 0.90 ADORA1 (0.50) ADORA1LMNAPPARGPPARAGAA
SCHEMBL7986064 0.88 ADORA1 (0.50) ADORA1NPC1ALDH1A1MAPTSMN1; SMN2
SCHEMBL7986216 0.86 ADORA1 (0.33) ADORA1MC4RMC3RNPC1ALDH1A1
Trifluoroacetic Acid SCHEMBL7986775 0.85 ITGB3 (0.46) ADORA1MC4RMC3RNPC1LMNA
SCHEMBL7986071 0.81 ADORA1 (0.52) ADORA1KMT2A
SCHEMBL7992050 0.81 ADORA1 (0.52) ADORA1KMT2A
SCHEMBL7992666 0.81 ADORA1 (0.56) ADORA1KMT2A
SCHEMBL7986065 0.80 ADORA1 (0.51) ADORA1PPARGPPARAKMT2A
SCHEMBL7975232 0.79 ADORA1 (0.51) ADORA1KMT2A
SCHEMBL7985657 0.78 ADORA1 (0.50) ADORA1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed