Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394315 | 0.91 | SMN1; SMN2 (0.50) | L3MBTL1SMN1; SMN2MEN1KMT2AKCNH2 | |
| Oxalic Acid SCHEMBL7988348 | 0.84 | SMN1; SMN2 (0.49) | L3MBTL1SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7961178 | 0.82 | HRH3 (0.58) | L3MBTL1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7974811 | 0.80 | TDP1 (0.51) | L3MBTL1KCNH2ALDH1A1 | |
| Oxalic Acid SCHEMBL7990912 | 0.80 | MEN1 (0.47) | L3MBTL1SMN1; SMN2PPARDPPARAMEN1 | |
| SCHEMBL4381007 | 0.80 | SMN1; SMN2 (0.52) | L3MBTL1SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7971202 | 0.80 | MAPT (0.60) | L3MBTL1SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7974440 | 0.80 | GAA (0.56) | L3MBTL1SMN1; SMN2PPARAMEN1KMT2A | |
| SCHEMBL7971472 | 0.79 | HRH3 (0.48) | SMN1; SMN2ATMNPC1MEN1KMT2A | |
| Oxalic Acid SCHEMBL7991422 | 0.79 | HRH2 (0.39) | SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |