Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7988348 | 0.96 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1MAPTRAB9AHPGD | |
| SCHEMBL7977335 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1MAPTRAB9AHPGD | |
| SCHEMBL7961178 | 0.86 | HRH3 (0.58) | SMN1; SMN2MAPTGAAHRH3L3MBTL1 | |
| SCHEMBL4379265 | 0.85 | KMT2A (0.46) | SMN1; SMN2NPC1MAPTRAB9AHPGD | |
| SCHEMBL7974811 | 0.84 | TDP1 (0.51) | MAPTHRH3L3MBTL1 | |
| SCHEMBL7971202 | 0.84 | MAPT (0.60) | SMN1; SMN2NPC1MAPTRAB9AGAA | |
| SCHEMBL7987565 | 0.83 | L3MBTL1 (0.55) | SMN1; SMN2NPC1MAPTHRH3L3MBTL1 | |
| SCHEMBL7991268 | 0.82 | HRH3 (0.57) | NPC1RAB9AHRH3HRH2HRH1 | |
| SCHEMBL7990745 | 0.81 | HRH2 (0.57) | L3MBTL1HRH2HRH1 | |
| SCHEMBL7974440 | 0.81 | GAA (0.56) | SMN1; SMN2MAPTHPGDGAAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| WO-1996031526-A1 | ANTI-OBESITY AGENTS | AMYLIN PHARMACEUTICALS, INC. (US) | 1996-10-10 | — | — | WO | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |