Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381007 | 0.96 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTRAB9ANPC1HPGD | |
| SCHEMBL7977335 | 0.90 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTRAB9ANPC1HPGD | |
| Oxalic Acid SCHEMBL7987116 | 0.84 | L3MBTL1 (0.49) | SMN1; SMN2NPC1ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7961178 | 0.83 | HRH3 (0.58) | SMN1; SMN2MAPTGAAHRH3ALDH1A1 | |
| SCHEMBL4379265 | 0.81 | KMT2A (0.46) | SMN1; SMN2MAPTRAB9ANPC1HPGD | |
| SCHEMBL7974811 | 0.81 | TDP1 (0.51) | MAPTHRH3ALDH1A1L3MBTL1 | |
| SCHEMBL7974440 | 0.81 | GAA (0.56) | SMN1; SMN2MAPTHPGDGAAHRH3 | |
| SCHEMBL7971202 | 0.81 | MAPT (0.60) | SMN1; SMN2MAPTRAB9ANPC1GAA | |
| SCHEMBL7987565 | 0.80 | L3MBTL1 (0.55) | SMN1; SMN2MAPTNPC1HRH3ALDH1A1 | |
| Oxalic Acid SCHEMBL7990912 | 0.79 | MEN1 (0.47) | SMN1; SMN2MAPTHPGDHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |