Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386689 | 0.92 | LMNA (0.45) | LMNAMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7973104 | 0.85 | MAPT (0.43) | LMNAMAPTL3MBTL1ALDH1A1HPGD | |
| SCHEMBL4378580 | 0.84 | KDM4E (0.43) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| Oxalic Acid SCHEMBL7991422 | 0.84 | HRH2 (0.39) | MAPTALDH1A1SMN1; SMN2KDM4EHRH3 | |
| SCHEMBL4378557 | 0.83 | POLB (0.42) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| Oxalic Acid SCHEMBL7991342 | 0.83 | LMNA (0.54) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4378585 | 0.82 | ALDH1A1 (0.53) | MEN1KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL4383468 | 0.81 | KDM4E (0.44) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7991257 | 0.81 | CYP3A4 (0.45) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4383472 | 0.81 | ALDH1A1 (0.46) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |