Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.58 |
| ▸ | FLT1 | P17948 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554499 | 0.91 | KDR (0.53) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7548593 | 0.91 | KDR (0.57) | KDRFLT1FLT4GSK3BMAPK14 | |
| SCHEMBL7987884 | 0.89 | KDR (0.52) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7990494 | 0.88 | KDR (0.51) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7990540 | 0.87 | KDR (0.75) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7554860 | 0.87 | CYP1A2 (0.49) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7502516 | 0.85 | KDR (0.77) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7556924 | 0.84 | KDR (0.59) | KDRFLT1FLT4GSK3BNFATC1 | |
| SCHEMBL7548014 | 0.84 | KDR (0.43) | KDRFLT1FLT4GSK3B | |
| SCHEMBL7547227 | 0.84 | KDR (0.60) | KDRFLT1FLT4GSK3BNFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |