Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | FLT1 | P17948 | 4/20 | 0.51 |
| ▸ | FLT4 | P35916 | 4/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7556924 | 0.94 | KDR (0.59) | KDRFLT1FLT4GSK3BHRH3 | |
| SCHEMBL7555532 | 0.91 | KDR (0.52) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7987209 | 0.91 | KDR (0.58) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7988086 | 0.89 | KDR (0.51) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7986847 | 0.88 | KDR (0.50) | KDRFLT1FLT4MAPK14SIGMAR1 | |
| SCHEMBL7993940 | 0.87 | KDR (0.74) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7551471 | 0.86 | KDR (0.49) | KDRFLT1FLT4BACE1LTA4H | |
| SCHEMBL7548014 | 0.85 | KDR (0.43) | KDRFLT1FLT4GRIN1GRIN2B | |
| SCHEMBL7987168 | 0.85 | KDR (0.54) | KDRFLT1FLT4MAPK14GSK3B | |
| SCHEMBL7547227 | 0.85 | KDR (0.60) | KDRFLT1FLT4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |