Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.42 |
| ▸ | FLT4 | P35916 | 3/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553729 | 0.92 | KDR (0.40) | KDRFLT1FLT4LTA4HGSK3B | |
| SCHEMBL7553655 | 0.90 | KDR (0.39) | KDRFLT1FLT4GSK3BGRIN1 | |
| SCHEMBL7551721 | 0.90 | CHRNB1 (0.39) | KDRFLT1FLT4LTA4HGSK3B | |
| SCHEMBL7557708 | 0.89 | KDR (0.56) | KDRFLT1FLT4GSK3BDRD2 | |
| SCHEMBL7549687 | 0.88 | AVPR1B (0.38) | KDRFLT1FLT4CHRNB1CHRNB2 | |
| SCHEMBL7549926 | 0.87 | KDR (0.57) | KDRFLT1FLT4GSK3BEGLN1 | |
| SCHEMBL7548593 | 0.85 | KDR (0.57) | KDRFLT1FLT4LTA4HGSK3B | |
| SCHEMBL7987209 | 0.84 | KDR (0.58) | KDRFLT1FLT4GSK3B | |
| SCHEMBL7550735 | 0.83 | KDR (0.42) | KDRFLT1FLT4LTA4HCHRNB1 | |
| SCHEMBL7509366 | 0.81 | KDR (0.47) | KDRFLT1FLT4LTA4HGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |