Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981731 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL12958860 | 0.88 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL1111647 | 0.88 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL8002663 | 0.87 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL7996732 | 0.86 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL3427843 | 0.86 | CHRNA7 (0.59) | ITKCHRNA7NAMPTEPHX2 | |
| SCHEMBL12900635 | 0.86 | ALDH1A1 (0.49) | CHRNA7ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7987284 | 0.86 | EPHX2 (0.56) | CHRNA7ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1269992 | 0.86 | ALDH1A1 (0.43) | CHRNA7ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL1111666 | 0.85 | HPGDS (0.59) | ITKEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283365-B2 | Indole modulators of the alpha 7 nicotinic acetylcholine receptor | PROXIMAGEN LIMITED (GB) | 2012-10-09 | — | — | US | claimed |
| EP-2279184-B1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | PROXIMAGEN LTD (GB) | 2012-08-08 | — | — | EP | claimed |
| US-8283365-B2 | Indole modulators of the alpha 7 nicotinic acetylcholine receptor | PROXIMAGEN LIMITED (GB) | 2012-10-09 | — | — | US | disclosed |
| US-8283365-B2 | Indole modulators of the alpha 7 nicotinic acetylcholine receptor | PROXIMAGEN LIMITED (GB) | 2012-10-09 | — | — | US | disclosed |
| US-8283365-B2 | Indole modulators of the alpha 7 nicotinic acetylcholine receptor | PROXIMAGEN LIMITED (GB) | 2012-10-09 | — | — | US | disclosed |
| US-20120252853-A1 | Positive allosteric modulators of nicotinic acetylcholine receptor | H. LUNDBECK A/S (DK) | 2012-10-04 | — | — | US | disclosed |
| WO-2012131031-A1 | NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | H. LUNDBECK A/S (DK) | 2012-10-04 | — | — | WO | disclosed |
| US-20120252853-A1 | Positive allosteric modulators of nicotinic acetylcholine receptor | H. LUNDBECK A/S (DK) | 2012-10-04 | — | — | US | disclosed |
| US-20120252853-A1 | Positive allosteric modulators of nicotinic acetylcholine receptor | H. LUNDBECK A/S (DK) | 2012-10-04 | — | — | US | disclosed |
| EP-2279184-B1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | PROXIMAGEN LTD (GB) | 2012-08-08 | — | — | EP | disclosed |
| EP-2279184-B1 | INDOLE MODULATORS OF THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR | PROXIMAGEN LTD (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | GLAXOSMITHKLINE SERVICES UNLIMITED (GB) | 2011-02-10 | — | — | US | disclosed |
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | GLAXOSMITHKLINE SERVICES UNLIMITED (GB) | 2011-02-10 | — | — | US | disclosed |
| WO-2009127678-A1 | INDOLES AS MODULATORS OF NICOTINIC ACETYLCHOLIN RECEPTOR SUBTYPE ALPHA-71 | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252853-A1 | Positive allosteric modulators of nicotinic acetylcholine receptor | CHRNG, CHRNA7, CHRNA2 | ITK 3985/4885CHRNA7 2/4885NAMPT 244/4885 |
| US-20110034515-A1 | INDOLE MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR | CHRNA7, CHRNA5, CHRNG | ITK 3267/4885CHRNA7 1/4885NAMPT 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.