Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.44 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985844 | 0.90 | GAA (0.52) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7989309 | 0.90 | ROCK2 (0.55) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7974016 | 0.89 | GAA (0.56) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7988931 | 0.88 | GRIN1 (0.44) | ROCK2GAARXFP1NPY5R | |
| SCHEMBL7985650 | 0.87 | GAA (0.49) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7984692 | 0.86 | GAA (0.48) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7974310 | 0.86 | GAA (0.48) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7974092 | 0.86 | GAA (0.51) | ROCK2GAATP53RXFP1ROCK1 | |
| SCHEMBL7985331 | 0.86 | GRIN1 (0.45) | ROCK2GAARXFP1KDM4C | |
| SCHEMBL7988656 | 0.86 | NPY5R (0.44) | GAARXFP1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |