Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTSV | O60911 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993363 | 0.84 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1TDP1CASP7 | |
| SCHEMBL27686975 | 0.76 | TDP1 (0.46) | ALDH1A1L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL11331546 | 0.75 | MAPT (0.62) | ALDH1A1L3MBTL1MAPK1TDP1MEN1 | |
| SCHEMBL622250 | 0.75 | MAPT (0.47) | ALDH1A1L3MBTL1MAPK1TDP1MEN1 | |
| SCHEMBL16174932 | 0.74 | TDP1 (0.67) | ALDH1A1L3MBTL1MAPK1TDP1CASP7 | |
| SCHEMBL7990043 | 0.74 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1MAPK1TDP1CASP7 | |
| SCHEMBL9792985 | 0.72 | TDP1 (0.46) | ALDH1A1L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL8136793 | 0.72 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1MAPK1TDP1MEN1 | |
| SCHEMBL14420116 | 0.72 | TDP1 (0.49) | ALDH1A1L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL30354998 | 0.72 | RAB9A (0.60) | ALDH1A1L3MBTL1MAPK1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |