Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174932 | 0.85 | TDP1 (0.67) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL7987510 | 0.84 | ALDH1A1 (0.46) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL11900980 | 0.81 | TDP1 (0.58) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL194254 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL31040071 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL3205552 | 0.79 | TDP1 (0.74) | ALDH1A1MAPK1L3MBTL1TDP1CASP7 | |
| SCHEMBL2220068 | 0.78 | MEN1 (0.52) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL2220075 | 0.78 | MEN1 (0.52) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL3397565 | 0.78 | MAPT (0.64) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 | |
| SCHEMBL16174884 | 0.78 | MAPT (0.54) | ALDH1A1MAPK1L3MBTL1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |