Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | CHKA | P35790 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3439980 | 0.95 | POLB (0.73) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL7048817 | 0.90 | MAPT (0.85) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL1851861 | 0.88 | MAPT (0.89) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL378458 | 0.84 | MAPT (0.96) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL6151230 | 0.84 | SIRT6 (0.81) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL15271381 | 0.84 | SIRT6 (0.81) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL223626 | 0.83 | MAPT (1.00) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL85552 | 0.83 | MAPT (1.00) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL6607374 | 0.83 | MAPT (1.00) | MAPTLMNAPOLBSIRT6ALDH1A1 | |
| SCHEMBL1509517 | 0.81 | POLB (1.00) | MAPTLMNAPOLBSIRT6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333320-B1 | USEFUL AS DRUGS, ESPECIALLY AS AN ACTIVATED BLOOD COAGULATION FACTOR X INHIBITOR | Yamanouchi Pharmaceutical Co. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1000936-A1 | NOVEL HEXAHYDRO-1,4-DIAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-05-17 | — | — | EP | disclosed |