Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.38 |
| ▸ | RHOC | P08134 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376612 | 0.92 | MCHR1 (0.43) | CHRM1HTR2AMCHR1RHOCRHOA | |
| Oxalic Acid SCHEMBL7994699 | 0.85 | CHEK1 (0.37) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| Oxalic Acid SCHEMBL7991460 | 0.85 | TP53 (0.37) | CHRM1HTR2AMCHR1NPC1RAB9A | |
| Oxalic Acid SCHEMBL7990904 | 0.76 | RXFP1 (0.43) | RAB9AALDH1A1MEN1GAAMAPT | |
| Oxalic Acid SCHEMBL7991119 | 0.76 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7973065 | 0.76 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4389350 | 0.76 | CXCR4 (0.41) | CHRM1HTR2AMCHR1NPC1RAB9A | |
| SCHEMBL632032 | 0.74 | MAPT (0.44) | FFAR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7975024 | 0.74 | MEN1 (0.57) | SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL7994725 | 0.73 | L3MBTL1 (0.33) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |