Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7991460 | 0.85 | TP53 (0.37) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| Oxalic Acid SCHEMBL7987751 | 0.85 | CHRM1 (0.39) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4379745 | 0.82 | HPGD (0.43) | MAPTSMN1; SMN2ALDH1A1TDP1NPC1 | |
| SCHEMBL7994461 | 0.77 | RAB9A (0.47) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPK1 | |
| Oxalic Acid SCHEMBL7991119 | 0.77 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL4389350 | 0.77 | CXCR4 (0.41) | MAPTSMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL4376612 | 0.76 | MCHR1 (0.43) | MAPTSMN1; SMN2POLB | |
| SCHEMBL4376187 | 0.76 | L3MBTL1 (0.59) | MAPTSMN1; SMN2KDM4EALDH1A1POLB | |
| Oxalic Acid SCHEMBL7990904 | 0.74 | RXFP1 (0.43) | MAPTKDM4EALDH1A1TDP1RAB9A | |
| SCHEMBL7994725 | 0.71 | L3MBTL1 (0.33) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |