Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972926 | 0.88 | PKM (0.46) | NPC1RAB9ASMN1; SMN2L3MBTL1RECQL | |
| SCHEMBL7971223 | 0.88 | MEN1 (0.52) | NPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL7974587 | 0.88 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL7961372 | 0.87 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL6966124 | 0.87 | ROCK2 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1RECQL | |
| SCHEMBL7994461 | 0.85 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2RECQLHPGD | |
| SCHEMBL7960977 | 0.84 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL6968612 | 0.83 | ROCK2 (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1RECQL | |
| SCHEMBL7974343 | 0.83 | HRH4 (0.51) | — | |
| SCHEMBL8934796 | 0.82 | EPHX2 (0.46) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | claimed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | claimed |
| US-RE37303-E1 | Imidazole compounds and their therapeutic applications | INSTITUT NATIONAL DEL LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2001-07-31 | — | — | US | disclosed |
| US-5708171-A | HISTAMINE H3-RECEPTOR ANTAGONIST | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5559113-A | ANTAGONISTS TO HISTAMINE H3 RECEPTORS, SEDATIVES, ANTICONVULSANTS, ANTIULCER AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE | 1996-09-24 | — | — | US | disclosed |