Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 4/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6780495 | 0.87 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4PNMT | |
| SCHEMBL9091481 | 0.77 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29850336 | 0.72 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CPARP1 | |
| SCHEMBL6780272 | 0.71 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6786694 | 0.70 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8670950 | 0.70 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7617146 | 0.69 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL6785550 | 0.69 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6780845 | 0.67 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4PNMT | |
| SCHEMBL7983799 | 0.67 | GRIA1 (0.60) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197771-B1 | NERVOUS SYSTEM DISORDERS; ANTIISCHEMIC AGENTS; ALZHEIMER'SDISEASE; PARKINSON'S DISEASE; HUNTINGTON'S DISEASE | WARNER-LAMBERT COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6057313-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1996028445-A1 | NOVEL GLUTAMATE (AMPA/KAINATE) RECEPTOR ANTAGONISTS: N-SUBSTITUTED FUSED AZACYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-09-19 | — | — | WO | disclosed |