Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1RN | P18510 | 3/20 | 0.49 |
| ▸ | NMBR | P28336 | 2/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 8/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7975805 | 0.90 | ECE1 (0.53) | MAPK1SMN1; SMN2 | |
| SCHEMBL8810555 | 0.86 | TACR1 (0.49) | IL1RNNMBRERAP2ERAP1LNPEP | |
| SCHEMBL7990231 | 0.85 | NMBR (0.54) | IL1RNNMBRERAP2ERAP1LNPEP | |
| SCHEMBL7975851 | 0.84 | IL1RN (0.48) | IL1RNNMBRERAP2ERAP1LNPEP | |
| SCHEMBL7986305 | 0.83 | MAPK1 (0.56) | MAPK1SMN1; SMN2 | |
| SCHEMBL7993356 | 0.81 | ECE1 (0.59) | MAPK1SMN1; SMN2 | |
| SCHEMBL7993751 | 0.81 | TACR1 (0.48) | IL1RNERAP2ERAP1LNPEPMAPK1 | |
| SCHEMBL8810898 | 0.80 | TACR1 (0.47) | IL1RNERAP2ERAP1LNPEPMAPK1 | |
| SCHEMBL8807044 | 0.79 | TACR1 (0.47) | IL1RNERAP2ERAP1LNPEPMAPK1 | |
| SCHEMBL7976001 | 0.79 | ERAP2 (0.56) | IL1RNERAP2ERAP1LNPEPMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |