Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IL1RN | P18510 | 4/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810898 | 0.95 | TACR1 (0.47) | TACR1MAPK1SMN1; SMN2IL1RNERAP2 | |
| SCHEMBL7994280 | 0.94 | TACR1 (0.46) | TACR1MAPK1SMN1; SMN2IL1RNERAP2 | |
| SCHEMBL7986645 | 0.94 | TACR1 (0.45) | TACR1MAPK1SMN1; SMN2IL1RNERAP2 | |
| SCHEMBL7990070 | 0.93 | MAPK1 (0.47) | MAPK1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL7988163 | 0.88 | SMN1; SMN2 (0.44) | TACR1MAPK1SMN1; SMN2MEN1LMNA | |
| SCHEMBL7990508 | 0.88 | SMN1; SMN2 (0.44) | TACR1MAPK1SMN1; SMN2MEN1LMNA | |
| SCHEMBL8807798 | 0.88 | MAPK1 (0.46) | MAPK1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL7976826 | 0.87 | MAPK1 (0.45) | MAPK1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL7986462 | 0.86 | MAPK1 (0.44) | MAPK1SMN1; SMN2MEN1POLBKMT2A | |
| SCHEMBL7987522 | 0.84 | EDNRA (0.47) | SMN1; SMN2MEN1ALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |