Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 2/20 | 0.54 |
| ▸ | TACR1 | P25103 | 11/20 | 0.46 |
| ▸ | IL1RN | P18510 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987859 | 0.85 | IL1RN (0.49) | NMBRTACR1IL1RNERAP2ERAP1 | |
| SCHEMBL7975851 | 0.81 | IL1RN (0.48) | NMBRTACR1IL1RNERAP2ERAP1 | |
| SCHEMBL8810555 | 0.81 | TACR1 (0.49) | NMBRTACR1IL1RNERAP2ERAP1 | |
| SCHEMBL7993751 | 0.80 | TACR1 (0.48) | TACR1IL1RNERAP2ERAP1LNPEP | |
| SCHEMBL8810898 | 0.79 | TACR1 (0.47) | TACR1IL1RNERAP2ERAP1LNPEP | |
| SCHEMBL7986305 | 0.79 | MAPK1 (0.56) | MEN1MAPTKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL7994280 | 0.78 | TACR1 (0.46) | TACR1IL1RNERAP2ERAP1LNPEP | |
| SCHEMBL7986645 | 0.78 | TACR1 (0.45) | TACR1IL1RNERAP2ERAP1LNPEP | |
| SCHEMBL7986471 | 0.77 | EDNRA (0.54) | — | |
| SCHEMBL7993356 | 0.77 | ECE1 (0.59) | MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |