Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549809 | 0.94 | HTR6 (0.43) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7555466 | 0.90 | PDE4B (0.46) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7990227 | 0.90 | PDE4B (0.45) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7990418 | 0.89 | KDR (0.39) | PDE4BPDE4DCYP11B1CYP11B2CYP17A1 | |
| SCHEMBL7976435 | 0.88 | PRKCA (0.42) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7550632 | 0.87 | PDE4B (0.43) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7550587 | 0.85 | KDR (0.49) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7552885 | 0.85 | KDR (0.51) | PDE4BPDE4DHTR6FLT1FLT4 | |
| SCHEMBL7516192 | 0.85 | KDR (0.54) | PDE4BPDE4DHTR6CYP11B1CYP11B2 | |
| SCHEMBL7991178 | 0.85 | KDR (0.54) | PDE4BPDE4DHTR6FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |