Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977915 | 1.00 | PAK4 (0.42) | PAK4L3MBTL1PIM1PIM2IDO1 | |
| SCHEMBL6979734 | 0.93 | L3MBTL1 (0.45) | PAK4L3MBTL1GRK5PDPK1SMN1; SMN2 | |
| SCHEMBL6979739 | 0.93 | L3MBTL1 (0.45) | PAK4L3MBTL1GRK5PDPK1SMN1; SMN2 | |
| SCHEMBL7225808 | 0.88 | LRRK2 (0.43) | PAK4PIM1PIM2IDO1PDPK1 | |
| SCHEMBL7225806 | 0.88 | LRRK2 (0.43) | PAK4PIM1PIM2IDO1PDPK1 | |
| SCHEMBL8192683 | 0.87 | SMN1; SMN2 (0.48) | PAK4KDRSMN1; SMN2NAMPT | |
| SCHEMBL6985634 | 0.87 | ROCK2 (0.42) | PAK4L3MBTL1GRK5PDPK1NAMPT | |
| SCHEMBL6985636 | 0.87 | ROCK2 (0.42) | PAK4L3MBTL1GRK5PDPK1NAMPT | |
| SCHEMBL7982075 | 0.87 | PAK4 (0.43) | PAK4KDRSMN1; SMN2 | |
| SCHEMBL6980872 | 0.87 | PAK4 (0.43) | PAK4KDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |