Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979734 | 1.00 | L3MBTL1 (0.45) | L3MBTL1PAK4KMT2APDK2ALDH1A1 | |
| SCHEMBL8192683 | 0.94 | SMN1; SMN2 (0.48) | PAK4ALDH1A1GAAPOLBHTT | |
| SCHEMBL6977915 | 0.93 | PAK4 (0.42) | L3MBTL1PAK4KMT2APDK2GRK5 | |
| SCHEMBL7987909 | 0.93 | PAK4 (0.42) | L3MBTL1PAK4KMT2APDK2GRK5 | |
| SCHEMBL2568750 | 0.92 | L3MBTL1 (0.45) | L3MBTL1KMT2APDK2ALDH1A1KDM4E | |
| SCHEMBL6985636 | 0.90 | ROCK2 (0.42) | L3MBTL1PAK4GRK5CYP3A4PDPK1 | |
| SCHEMBL6985634 | 0.90 | ROCK2 (0.42) | L3MBTL1PAK4GRK5CYP3A4PDPK1 | |
| SCHEMBL6980866 | 0.89 | SIGMAR1 (0.45) | KMT2AKDM4EGRK5GAANAMPT | |
| SCHEMBL6980870 | 0.89 | SIGMAR1 (0.45) | KMT2AKDM4EGRK5GAANAMPT | |
| SCHEMBL6986773 | 0.88 | LMNA (0.42) | L3MBTL1PAK4GRK5CYP3A4PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |