Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359641 | 0.86 | GABRA1 (0.39) | GABRA1GABRB2ESR1ESR2 | |
| SCHEMBL9356205 | 0.83 | TYR (0.41) | ESR1 | |
| SCHEMBL28093477 | 0.80 | TRPA1 (0.32) | GABRA1GABRB2ESR1ESR2 | |
| SCHEMBL9674011 | 0.78 | NOS3 (0.35) | — | |
| SCHEMBL9359711 | 0.78 | GABRA1 (0.38) | GABRA1GABRB2ESR1ESR2 | |
| SCHEMBL125379 | 0.76 | GABRA1 (0.30) | GABRA1GABRB2 | |
| SCHEMBL458201 | 0.76 | NOS3 (0.32) | GABRA1GABRB2 | |
| SCHEMBL7989382 | 0.75 | PRKCI (0.33) | GABRA1GABRB2 | |
| SCHEMBL3422479 | 0.74 | NOS3 (0.31) | — | |
| SCHEMBL458751 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |
| EP-0457730-B1 | Process for preparation of thioderivatives of alkylhydroxyanilinotriazine | CIBA GEIGY AG (CH) | 1994-11-09 | — | — | EP | disclosed |
| EP-0324431-B1 | NEW INDOLYLPIPERIDINE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-5086173-A | Hydrogenating in presence of palladium catalyst without isolating the intermediates | CIBA-GEIGY CORPORATION (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0457730-A2 | Process for preparation of thioderivatives of alkylhydroxyanilinotriazine | CIBA-GEIGY AG (CH) | 1991-11-21 | — | — | EP | disclosed |
| US-5017703-A | Antiallergens, antiinflammatory | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| US-4935432-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-06-19 | — | — | US | disclosed |
| EP-0324431-A1 | New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-19 | — | — | EP | disclosed |