Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLQ | O75417 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flubanilate SCHEMBL1404126 | 0.87 | ALOX15 (0.46) | TSHRCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL10870789 | 0.87 | ALOX15 (0.48) | TSHRCYP1A2CYP3A4CYP2C19MEN1 | |
| Flubanilate SCHEMBL121907 | 0.86 | ALOX15 (0.45) | TSHRCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL9224528 | 0.85 | TSHR (0.50) | TSHRCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL9357893 | 0.84 | LMNA (0.57) | TSHRMEN1KMT2APOLQMAPT | |
| SCHEMBL2095059 | 0.82 | HPGD (0.50) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL10871800 | 0.81 | ALOX15 (0.47) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL27919587 | 0.81 | POLQ (0.55) | TSHRMEN1KMT2APOLQMAPT | |
| SCHEMBL6227930 | 0.80 | ALDH1A1 (0.53) | TSHRCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL1400828 | 0.77 | ALDH1A1 (0.63) | TSHRCYP1A2CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |