Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555367 | 0.95 | KDR (0.51) | KDRCNR2FLT1FLT4BACE1 | |
| SCHEMBL7976879 | 0.92 | KDR (0.50) | KDRCNR2FLT1FLT4ALDH1A1 | |
| SCHEMBL7549676 | 0.92 | KDR (0.50) | KDRCNR2FLT1FLT4FLT3 | |
| SCHEMBL7551199 | 0.92 | KDR (0.54) | KDRCNR2FLT1FLT4BACE1 | |
| SCHEMBL7550092 | 0.90 | KDR (0.49) | KDRCNR2FLT1FLT4FLT3 | |
| SCHEMBL7556041 | 0.87 | KDR (0.53) | KDRCNR2FLT1FLT4BRD4 | |
| SCHEMBL7550119 | 0.87 | CNR2 (0.40) | KDRCNR2FLT1FLT4BRD4 | |
| SCHEMBL7554271 | 0.87 | KDR (0.49) | KDRCNR2FLT1FLT4FLT3 | |
| SCHEMBL7554226 | 0.87 | KDR (0.66) | KDRFLT1FLT4BACE1FLT3 | |
| SCHEMBL7549404 | 0.86 | KDR (0.51) | KDRCNR2FLT1FLT4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |